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Minotti m el.
5 6 epigenetic silencing.
Epigenetic aberrations play a crucial role in cancer initiation and progression.
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In patients with right mtle group difference functional connectivity maps rmtle controls showed for ra and rh decreased connectivity with the brain areas of the default mode network dmn the ventromesial limbic prefrontal regions and contralateral mesial temporal structures.
And for la and lh decreased connectivity with dmn and contralateral hippocampus.
1 2 the most common epigenetic alterations in cancer are dna methylation and histone modifications.
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3 4 these epigenetic changes lead to silencing of tumor suppressor genes involved in key dna damage response pathways such as cell cycle control apoptosis and dna repair.